Pouleur H, van Eyll C, Etienne J, van Mechelen H, Vuylsteke A, Rousseau M F
Department of Physiology, University of Louvain, Brussels, Belgium.
Basic Res Cardiol. 1989;84 Suppl 1:157-62. doi: 10.1007/BF02650355.
Myocardial oxygen uptake and an index of mechanical left ventricular efficiency were determined in basal conditions or during prolonged therapy with the new beta 1-adrenoceptor partial agonist xamoterol in 16 patients with mild to moderate ischemic heart failure. During xamoterol therapy, left ventricular end-diastolic pressure decreased from 24.4 +/- 6.5 to 17.8 +/- 8.6 mm Hg (P less than 0.01) and the isovolumic index of inotropic state (dP/dt)/DP40 increased by 14% (P less than 0.01). The heart rate increased slightly and the mean systolic and peak systolic wall stress also tended to increase (+ 7%; NS) but myocardial oxygen uptake (14.1 vs 14.7 ml/min; NS) and the index of efficiency (8.77 +/- 3.44 to 8.82 +/- 4.27; NS) were not significantly modified. In conclusion, prolonged therapy with xamoterol was not accompanied by a deterioration in the mechanical efficiency of the ventricle, even in patients with ischemic heart disease.
在16例轻至中度缺血性心力衰竭患者中，测定了基础状态下以及使用新型β1 -肾上腺素能受体部分激动剂扎莫特罗进行长期治疗期间的心肌氧摄取量和左心室机械效率指标。在扎莫特罗治疗期间，左心室舒张末期压力从24.4±6.5降至17.8±8.6 mmHg（P<0.01），变力状态等容指数（dP/dt）/DP40增加了14%（P<0.01）。心率略有增加，平均收缩压和收缩期峰值壁应力也有升高趋势（+7%；无统计学意义），但心肌氧摄取量（14.1对14.7 ml/min；无统计学意义）和效率指标（8.77±3.44至8.82±4.27；无统计学意义）无显著改变。总之，即使在缺血性心脏病患者中，扎莫特罗的长期治疗也未伴随心室机械效率的恶化。
