人和小鼠的白三烯代谢与超敏反应

Leukotriene metabolism and hypersensitivity in man and mouse.

作者信息

Card G L, Unnithan T, Rhodes M J, Wright B E

机构信息

Division of Biological Sciences, University of Montana, Missoula 59812.

出版信息

Biochem Biophys Res Commun. 1989 Oct 31;164(2):626-30. doi: 10.1016/0006-291x(89)91506-4.

DOI:10.1016/0006-291x(89)91506-4

PMID:2573348

Abstract

The relative rates of cysteinyl-leukotriene metabolism were analyzed in fresh human and mouse serum. Human serum contained higher gamma-glutamyl-transpeptidase activity than mouse serum, and a higher percentage of the metabolized leukotriene C4 was recovered as leukotriene D4 in the human serum than in the mouse serum. The results suggest that the patterns of metabolism of the cysteinyl-leukotrienes could be an important factor in determining the relative sensitivity of an animal to the development of hypersensitivity reactions.

摘要

在新鲜的人血清和小鼠血清中分析了半胱氨酰白三烯的代谢相对速率。人血清中的γ-谷氨酰转肽酶活性高于小鼠血清，并且与人血清相比，在小鼠血清中作为白三烯D4回收的代谢白三烯C4的百分比更高。结果表明，半胱氨酰白三烯的代谢模式可能是决定动物对超敏反应发展相对敏感性的一个重要因素。