经验性万古霉素在发热性中性粒细胞减少症肿瘤患者中的应用。
Empiric vancomycin use in febrile neutropenic oncology patients.
机构信息
Virginia Commonwealth University School of Pharmacy, Falls Church, Virginia.
Virginia Commonwealth University School of Pharmacy, Falls Church, Virginia ; Department of Pharmacotherapy and Outcome Sciences.
出版信息
Open Forum Infect Dis. 2014 Apr 10;1(1):ofu006. doi: 10.1093/ofid/ofu006. eCollection 2014 Mar.
Abstract
Vancomycin is commonly added as empiric therapy for febrile neutropenia. A retrospective chart review was conducted at a large community teaching institution to evaluate vancomycin use in oncology patients. The results revealed that a majority of empiric vancomycin therapy was inappropriate, raising concern for antibiotic resistance and prompting opportunities for improvement.
摘要
万古霉素常被添加作为发热性中性粒细胞减少症的经验性治疗。在一家大型社区教学医院进行了一项回顾性图表审查，以评估肿瘤患者中万古霉素的使用情况。结果表明，大多数经验性万古霉素治疗是不恰当的，这引起了对抗生素耐药性的关注，并为改进提供了机会。
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本文引用的文献
1
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Clin Infect Dis. 2013 Oct;57(7):1005-13. doi: 10.1093/cid/cit318. Epub 2013 May 10.
2
Deviations from guideline-based therapy for febrile neutropenia in cancer patients and their effect on outcomes.癌症患者发热性中性粒细胞减少症的指南治疗偏差及其对结局的影响。
JAMA Intern Med. 2013 Apr 8;173(7):559-68. doi: 10.1001/jamainternmed.2013.2921.
3
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.拯救脓毒症运动：严重脓毒症和脓毒性休克管理国际指南，2012 年。
Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.
4
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Pharmacotherapy. 2012 Aug;32(8):722-34. doi: 10.1002/j.1875-9114.2012.01162.x.
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