β受体阻滞剂治疗期间腓肠神经的配对刺激与功能变化

Paired stimulation and functional change of the sural nerve during beta blocker therapy.

作者信息

Husstedt I W, Grotemeyer K H, Schlake H P, Brune G

机构信息

Department of Neurology, University of Münster.

出版信息

Clin Neurol Neurosurg. 1989;91(4):311-6. doi: 10.1016/0303-8467(89)90006-1.

DOI:10.1016/0303-8467(89)90006-1

PMID:2573441

Abstract

29 patients were examined during a therapy with beta blockers. The medication was applied over 12 weeks, 16 patients received propranolol 120 mg/day, 13 patients metoprolol 200 mg/day. Two patients showed side-effects. Neurophysiological examinations, i.e. sural nerve conduction velocity and paired stimulation of the sural nerve, revealed a slight decrease of nerve conduction velocity and a significant increase of the latency prolongation of the second nerve action potential when the medication was finished. These functional changes in the sural nerve may result from the interaction of metoprolol and propranolol with beta-receptors of the peripheral nerve.

摘要

29名患者在接受β受体阻滞剂治疗期间接受了检查。药物治疗持续12周，16名患者每天服用120毫克普萘洛尔，13名患者每天服用200毫克美托洛尔。两名患者出现了副作用。神经生理学检查，即腓肠神经传导速度和腓肠神经的配对刺激，显示在药物治疗结束时神经传导速度略有下降，第二条神经动作电位的潜伏期延长显著增加。腓肠神经的这些功能变化可能是美托洛尔和普萘洛尔与外周神经β受体相互作用的结果。