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早期乳腺癌的术中放疗：潜在适应证及目前证据

Intraoperative radiotherapy in early stage breast cancer: potential indications and evidence to date.

作者信息

Hanna G G, Kirby A M

机构信息

1 Department of Clinical Oncology, Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK.

出版信息

Br J Radiol. 2015 May;88(1049):20140686. doi: 10.1259/bjr.20140686. Epub 2015 Mar 3.

DOI:10.1259/bjr.20140686
PMID:25734489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4628474/
Abstract

Following early results of recent studies of intraoperative radiotherapy (IORT) in the adjuvant treatment of patients with early breast cancer, the clinical utility of IORT is a subject of much recent debate within the breast oncology community. This review describes the intraoperative techniques available, the potential indications and the evidence to date pertaining to local control and toxicity. We also discuss any implications for current practice and future research.

摘要

根据近期关于术中放疗（IORT）在早期乳腺癌患者辅助治疗中的早期研究结果，IORT的临床应用价值是近期乳腺肿瘤学界众多讨论的主题。本综述描述了现有的术中技术、潜在适应证以及迄今为止有关局部控制和毒性的证据。我们还讨论了对当前实践和未来研究的任何影响。

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Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.65 岁或以上早期乳腺癌女性中保乳手术联合或不联合放疗（PRIME II）：一项随机对照试验。
Lancet Oncol. 2015 Mar;16(3):266-73. doi: 10.1016/S1470-2045(14)71221-5. Epub 2015 Jan 28.
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The impact of Oncotype DX testing on breast cancer management and chemotherapy prescribing patterns in a tertiary referral centre.Oncotype DX检测对三级转诊中心乳腺癌管理及化疗处方模式的影响。
Eur J Cancer. 2014 Nov;50(16):2763-70. doi: 10.1016/j.ejca.2014.08.002. Epub 2014 Sep 15.
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Intraoperative radiation therapy in early breast cancer using a linear accelerator outside of the operative suite: an "image-guided" approach.术中放射治疗早期乳腺癌，在手术室外使用直线加速器：一种“图像引导”方法。
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1015-1023. doi: 10.1016/j.ijrobp.2014.04.038. Epub 2014 Jul 8.
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Early experience with ultrasound features after intrabeam intraoperative radiation for early stage breast cancer.早期乳腺癌术中腔内放疗后超声表现的早期经验。
J Surg Oncol. 2014 Jun;109(8):751-5. doi: 10.1002/jso.23581. Epub 2014 Feb 20.
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Radiotherapy for breast cancer, the TARGIT-A trial.乳腺癌放疗，TARGIT - A试验。
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Breast J. 2014 Mar-Apr;20(2):125-30. doi: 10.1111/tbj.12235. Epub 2013 Dec 26.
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