大鼠下颌下腺导管细胞系中的A系统氨基酸转运
System A amino acid transport in a rat submandibular ductal cell line.
作者信息
Brown A M, Baum B J
机构信息
Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20857.
出版信息
Comp Biochem Physiol A Comp Physiol. 1989;93(2):383-9. doi: 10.1016/0300-9629(89)90052-2.
PMID:2573455
Abstract
- Neutral amino acid transport was studied in an established cell line derived from rat submandibular glands, RSMTx. 2. The greatest portion of alpha-amino isobutyrate (AIB) transport is mediated by system A. This component is Na+ dependent, pH sensitive, markedly inhibited by methyl AIB and enhanced 2-5-fold by amino acid depletion. 3. Evidence for the presence of other neutral amino acid transport systems, presumably ASC and L, was also found in these cells.
摘要
- 在一种源自大鼠下颌下腺的成熟细胞系RSMTx中研究了中性氨基酸转运。2. α-氨基异丁酸（AIB）转运的最大部分由A系统介导。该成分依赖于Na +，对pH敏感，被甲基AIB显著抑制，并在氨基酸耗竭时增强2至5倍。3. 在这些细胞中也发现了其他中性氨基酸转运系统（可能是ASC和L）存在的证据。
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