两种生长抑素类似物在水溶液中的构象。通过核磁共振方法和圆二色性进行研究。
Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism.
作者信息
Wynants C, Tourwe D, Kazmierski W, Hruby V J, Van Binst G
机构信息
Laboratory of Organic Chemistry, Vrije Universiteit Brussel, Belgium.
出版信息
Eur J Biochem. 1989 Nov 6;185(2):371-81. doi: 10.1111/j.1432-1033.1989.tb15125.x.
Cyclic-disulfide-containing analogues of somatostatin, Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7- Xaa8 [Xaa1 = H or DPhe; Xaa3 = Phe or Tyr; Xaa7 = Cys, Me2Cys or Me2DCys; Xaa8 = OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H-NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.
通过¹H-NMR光谱和圆二色性对含环二硫键的生长抑素类似物Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7-Xaa8 [Xaa1 = H或DPhe；Xaa3 = Phe或Tyr；Xaa7 = Cys、Me2Cys或Me2DCys；Xaa8 = OH、Thr8(OH)或Thr8NH2] 在水溶液中进行了研究。特别仔细地研究了二硫键的螺旋性质和环外残基的存在对生物活性的影响。
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