CDH13启动子甲基化在肺癌诊断作用中的定量评估
Quantitative assessment of the diagnostic role of CDH13 promoter methylation in lung cancer.
作者信息
Zhong Yun-Hua, Peng Hao, Cheng Hong-Zhong, Wang Ping
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming, Yunnan, PR China E-mail :
出版信息
Asian Pac J Cancer Prev. 2015;16(3):1139-43. doi: 10.7314/apjcp.2015.16.3.1139.
In order to explore the association between cadherin 13 (CDH13) gene promoter methylation and lung carcinoma (LC) risk, we carried out a meta-analysis with searching of PubMed, Web of Science. Ultimately, 17 articles were identified and analysised by STATA 12.0 software. Overall, we found a significant relationship between CDH13 promoter methylation and LC risk (odds ratio=6.98, 95% confidence interval: 4.21-11.56, p<0.001). Subgroup analyses further revealed that LC risk was increased for individuals carrying the methylated CDH13 compared with those with unmethylated CDH13. Hence, our study identified a strong association between CDH13 gene promoter methylation and LC and highlighted a promising potential for CDH13 methylation in LC risk prediction.
为了探讨钙黏蛋白13（CDH13）基因启动子甲基化与肺癌（LC）风险之间的关联，我们通过检索PubMed、Web of Science进行了一项荟萃分析。最终，通过STATA 12.0软件识别并分析了17篇文章。总体而言，我们发现CDH13启动子甲基化与LC风险之间存在显著关系（优势比=6.98，95%置信区间：4.21-11.56，p<0.001）。亚组分析进一步显示，与未甲基化CDH13的个体相比，携带甲基化CDH13的个体患LC的风险增加。因此，我们的研究确定了CDH13基因启动子甲基化与LC之间的强关联，并突出了CDH13甲基化在LC风险预测中的潜在前景。
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