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Nutrients. 2019 May 17;11(5):1102. doi: 10.3390/nu11051102.
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Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM concentrations.在不同 PM 浓度地区居住的不吸烟台湾成年人中，与吸烟相关的基因（AHRR）在 cg05575921 处的甲基化。
Clin Epigenetics. 2019 May 6;11(1):69. doi: 10.1186/s13148-019-0662-9.
4
SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas.SOX2 启动子在居住在空气污染区的不吸烟台湾成年人中的高甲基化。
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饮食脂肪与性别对 CDH13 cg02263260 甲基化的交互作用。

Interactive association between dietary fat and sex on CDH13 cg02263260 methylation.

机构信息

Institute of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan.

Division of Colon-Rectal Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan.

出版信息

BMC Med Genomics. 2021 Jan 6;14(1):13. doi: 10.1186/s12920-020-00858-y.

DOI:10.1186/s12920-020-00858-y
PMID:33407434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7788866/
Abstract

BACKGROUND

DNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults.

METHODS

Data of 870 eligible participants (430 men and 440 women) between 30 and 70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression.

RESULTS

The association between sex and cg02263260 methylation was significant: beta-coefficient (β) = 0.00532; 95% confidence interval (CI) = 0.00195-0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P-value = 0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (β = 0.00597; 95% CI = 0.00061-0.01133) and the test for trend was significant (P-value = 0.0283).

CONCLUSION

High fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases.

摘要

背景

黏附蛋白 13（CDH13）是一种抑癌基因，其 DNA 甲基化与基因沉默和癌变有关。我们确定了膳食脂肪和性别与台湾成年人 CDH13 cg02263260 甲基化的关系。

方法

从台湾生物银行（TWB）数据库中获取了 870 名 30 至 70 岁之间的合格参与者（男性 430 名，女性 440 名）的数据。使用多元线性回归来确定膳食脂肪和性别与 CDH13 cg02263260 甲基化的关系。

结果

性别与 cg02263260 甲基化之间的关联具有统计学意义：β 系数（β）=0.00532；95%置信区间（CI）=0.00195-0.00868。此外，性别和膳食脂肪对 cg02263260 甲基化的相互作用具有统计学意义（P 值=0.0145）。按性别分层后，仅在女性中，膳食脂肪与 cg02263260 甲基化之间存在关联。具体而言，高膳食脂肪与女性 cg02263260 甲基化呈正相关（β=0.00597；95%CI=0.00061-0.01133），且趋势检验具有统计学意义（P 值=0.0283）。

结论

高脂肪摄入与女性 cg02263260 甲基化水平升高显著相关，且趋势检验具有统计学意义。这些发现表明，脂肪摄入与 CDH13 cg02263260 之间的关联可能因性别而异，女性的 CDH13 cg02263260 甲基化水平可能随着脂肪摄入的增加而增加。