Wang Cong, Cai Xun-Zi, Yan Shi-Gui
Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
J Arthroplasty. 2015 Jul;30(7):1281-6. doi: 10.1016/j.arth.2015.02.005. Epub 2015 Feb 20.
The analgesic efficacy and safety of periarticular multimodal drug injection (PMDI) compared with femoral nerve block (FNB) for postoperative pain management in total knee arthroplasty (TKA) still remains controversial. We therefore conducted a meta-analysis to quantitatively compare PMDI to FNB in TKA. 10 randomized controlled trials (RCTs) with 744 TKAs in 728 patients were included in this study. The meta-analysis showed that single shot FNB may have better pain relief in the early postoperative period compared with single shot PMDI, and continuous PMDI provided postoperative analgesia comparable to that of continuous FNB. No significant difference was seen in regard to the complications between the two groups. However, due to the variation of the included studies, no firm conclusions can be drawn.
在全膝关节置换术（TKA）中，关节周围多模式药物注射（PMDI）与股神经阻滞（FNB）用于术后疼痛管理的镇痛效果和安全性仍存在争议。因此，我们进行了一项荟萃分析，以定量比较TKA中PMDI与FNB的效果。本研究纳入了10项随机对照试验（RCT），涉及728例患者的744例TKA。荟萃分析表明，与单次PMDI相比，单次FNB在术后早期可能具有更好的疼痛缓解效果，而持续PMDI提供的术后镇痛效果与持续FNB相当。两组之间在并发症方面未见显著差异。然而，由于纳入研究的差异，无法得出确凿结论。
