生物体液中苯海索、丙环定和环喷托酯的毛细管气相色谱法。

Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids.

作者信息

Owen J A, Sribney M, Lawson J S, Delva N, Letemendia F J

机构信息

Department of Psychiatry, Queen's University, Kingston Psychiatric Hospital, Ontario, Canada.

出版信息

J Chromatogr. 1989 Sep 29;494:135-42. doi: 10.1016/s0378-4347(00)82663-8.

DOI:10.1016/s0378-4347(00)82663-8

PMID:2573609

Abstract

A sensitive (50-100 pg/ml) method is described for the analysis of the anticholinergic drugs cycrimine, procyclidine and trihexyphenidyl by capillary gas chromatography with flame thermionic detection. Since these anticholinergic drugs are frequently administered in combination with antipsychotic medication for the treatment of mental illness, the potential interference by antipsychotic drugs in this assay was examined. No interference was observed from a series of antipsychotic drugs in the quantitation of cycrimine, procyclidine or trihexyphenidyl. The use of this technique to study trihexyphenidyl pharmacokinetics in man is described.

摘要

本文描述了一种灵敏的（50 - 100 pg/ml）方法，用于通过带有火焰热离子检测的毛细管气相色谱法分析抗胆碱能药物环喷托酯、丙环定和苯海索。由于这些抗胆碱能药物经常与抗精神病药物联合使用来治疗精神疾病，因此研究了该检测方法中抗精神病药物的潜在干扰。在环喷托酯、丙环定或苯海索的定量分析中，未观察到一系列抗精神病药物的干扰。还描述了使用该技术研究人体中苯海索药代动力学的情况。