Viswesh Velliyur, Yost Sarah E, Kaplan Bruce
College of Pharmacy, California Northstate University, 9700 West Taron Drive, Elk Grove, CA 95757, USA.
Department of Pharmacy, The University of Arizona Medical Center, University Campus, 1501 N. Campbell Ave, Tucson, AZ 85724, USA.
Transplant Rev (Orlando). 2015 Jul;29(3):175-80. doi: 10.1016/j.trre.2015.02.004. Epub 2015 Feb 24.
The significance of BK viruria and viremia in non-renal solid organ transplants is poorly understood. A systematic review was performed reviewing the incidence and implications of BK virus replication in non-renal solid organ transplants. Ninety-seven studies were identified, of which 18 including lung, heart, liver and pancreas transplants were included. The overall incidence of BK viruria and viremia was 20% and 3% respectively and 17 cases of BK nephropathy were identified. Heart transplant recipients had a higher overall incidence of BK viremia than other non-renal organ types, and the majority of cases of BK virus-associated nephropathy were in heart transplant recipients. The incidence of BK viremia was significantly lower in non-renal solid organ transplants than that of renal transplant recipients and BK virus-associated nephropathy was rare. BK virus-associated nephropathy may be considered in heart transplant recipients who have unexplained and persistent renal dysfunction not attributable to other causes.
BK病毒尿症和病毒血症在非肾实体器官移植中的意义尚未得到充分了解。我们进行了一项系统综述，回顾了BK病毒在非肾实体器官移植中的复制发生率及影响。共识别出97项研究，其中包括18项涉及肺、心脏、肝脏和胰腺移植的研究。BK病毒尿症和病毒血症的总体发生率分别为20%和3%，并识别出17例BK肾病病例。心脏移植受者的BK病毒血症总体发生率高于其他非肾器官类型，且大多数BK病毒相关性肾病病例发生在心脏移植受者中。非肾实体器官移植受者的BK病毒血症发生率显著低于肾移植受者，且BK病毒相关性肾病较为罕见。对于出现无法解释的持续性肾功能不全且非其他原因所致的心脏移植受者，可考虑BK病毒相关性肾病。
