Scherer W J, Udin S B
Department of Physiology, State University of New York, Buffalo 14214.
J Neurosci. 1989 Nov;9(11):3837-43. doi: 10.1523/JNEUROSCI.09-11-03837.1989.
Glutamate receptors appear to play a key role in several forms of experience-dependent modification of both the strength of synapses and synaptic connectivity. In developing Xenopus frogs, the connections made by isthmotectal axons relaying visual input from the eye to the ipsilateral tectum are markedly influenced by the visual activity of contralateral retinotectal axons, and normal binocular visual input is necessary in order for the ipsilateral visuotectal map to come into register with the contralateral map. We have tested whether NMDA receptors play a role in establishment of the topographic matching of binocular maps during development. We have examined the effects of chronic treatment of tectum with either the receptor agonist NMDA or the antagonists APV or CPP applied throughout early postmetamorphic life using subpial implants of drug-impregnated elvax. Both antagonists blocked the matching of the ipsilateral map to the contralateral map, while NMDA permitted such matching. Our data therefore indicate that NMDA receptors are involved in the experience-dependent establishment of matching binocular maps during development.
谷氨酸受体似乎在多种形式的依赖经验的突触强度和突触连接性修饰中发挥关键作用。在发育中的非洲爪蟾中，从眼睛向同侧视顶盖传递视觉输入的峡核 - 视顶盖轴突所形成的连接，受到对侧视网膜 - 视顶盖轴突视觉活动的显著影响，并且正常的双眼视觉输入对于同侧视觉 - 顶盖图谱与对侧图谱对齐是必要的。我们已经测试了NMDA受体在发育过程中双眼图谱的地形匹配建立中是否发挥作用。我们使用药物浸渍的乙烯 - 醋酸乙烯共聚物的软膜下植入物，研究了在整个变态后早期用受体激动剂NMDA或拮抗剂APV或CPP对视顶盖进行慢性处理的效果。两种拮抗剂都阻断了同侧图谱与对侧图谱的匹配，而NMDA则允许这种匹配。因此，我们的数据表明NMDA受体参与了发育过程中依赖经验的匹配双眼图谱的建立。
