孕妇子宫中的CD1抗原呈递与自身反应性
CD1 Antigen Presentation and Autoreactivity in the Pregnant Human Uterus.
作者信息
Guerin Leigh, Wu Vernon, Houser Brandy, Tilburgs Tamara, de Jong Annemieke, Moody D Branch, Strominger Jack L
机构信息
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Am J Reprod Immunol. 2015 Aug;74(2):126-35. doi: 10.1111/aji.12375. Epub 2015 Mar 4.
PROBLEM
CD11c(HI) human decidual macrophages express several isoforms of CD1 molecules. Their expression pattern and function required investigation.
METHOD OF STUDY
CD11c(HI) macrophages were isolated from decidua. Expression of CD1 isoforms and their ability to present lipid antigens to T cells was studied.
RESULTS
CD1a, CD1c, and CD1d were all expressed on CD11c(HI) dMϕ, a pattern differing from those previously observed. Exposure of peripheral monocytes and dendritic cells to lipid isolates from decidua led to increased surface CD1a levels only. The CD1a and CD1c on dMϕ were able to present the appropriate lipid antigens to lipid antigen-specific T cells. Finally, autoreactivity of decidual T cells to CD1a was observed.
CONCLUSION
The unique pattern of expression of CD1 isoforms on CD11c(HI) dMϕ is consistent with organ-specific roles of CD1 in human T-cell responses. dMϕ are able to present lipid antigens to both peripheral and decidual T cells and are major antigen-presenting cells in human decidua.
问题
CD11c(HI)人蜕膜巨噬细胞表达多种CD1分子异构体。其表达模式和功能有待研究。
研究方法
从蜕膜中分离出CD11c(HI)巨噬细胞。研究CD1异构体的表达及其向T细胞呈递脂质抗原的能力。
结果
CD1a、CD1c和CD1d均在CD11c(HI)蜕膜巨噬细胞上表达，这一模式与先前观察到的不同。外周单核细胞和树突状细胞暴露于来自蜕膜的脂质分离物仅导致表面CD1a水平升高。蜕膜巨噬细胞上的CD1a和CD1c能够将适当的脂质抗原呈递给脂质抗原特异性T细胞。最后，观察到蜕膜T细胞对CD1a的自身反应性。
结论
CD11c(HI)蜕膜巨噬细胞上CD1异构体的独特表达模式与CD1在人类T细胞反应中的器官特异性作用一致。蜕膜巨噬细胞能够将脂质抗原呈递给外周和蜕膜T细胞，并且是人类蜕膜中的主要抗原呈递细胞。
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