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从对具有与高血压相反特征的人体模型(巴特综合征和吉特林综合征)的研究中探讨高血压靶器官损伤病理生理学的机制方法。

Mechanistic approach to the pathophysiology of target organ damage in hypertension from studies in a human model with characteristics opposite to hypertension: Bartter's and Gitelman's syndromes.

作者信息

Calò L A, Maiolino G

机构信息

Department of Medicine, Nephrology and Hypertension, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.

出版信息

J Endocrinol Invest. 2015 Jul;38(7):711-6. doi: 10.1007/s40618-015-0249-z. Epub 2015 Mar 5.

Abstract

INTRODUCTION

Extensive studies using Bartter's/Gitelman's syndrome patients have provided insights into the angiotensin II (Ang II) signaling pathways involved in the regulation of vascular tone and cardiovascular-renal remodeling. The renin-angiotensin-aldosterone system is activated in these syndromes, however, patients do not develop hypertension and cardiovascular remodeling and clinically manifest conditions opposite to hypertension. The short- and the long-term signaling of Ang II remains an important matter of investigation to shed light on mechanisms responsible for the pathophysiology of hypertension and its long-term complications. The long-term signaling of Ang II is involved in the pathophysiology of cardiovascular-renal remodeling and inflammatory responses in which the balance between RhoA/Rho kinase pathway and NO system plays a crucial role.

METHODS AND RESULTS

In this brief review, the results of our studies in Bartter's and Gitelman's syndromes are reported on these processes.

CONCLUSIONS

The information obtained from these studies can clarify, confirm or be used to extend the biochemical mechanisms responsible for the pathophysiology of hypertension and its long-term complications and could offer further chances to identify additional potential significant targets of therapy.

摘要

引言

利用巴特综合征/吉特曼综合征患者开展的大量研究,为深入了解参与血管张力调节和心血管-肾脏重塑的血管紧张素II(Ang II)信号通路提供了线索。这些综合征中肾素-血管紧张素-醛固酮系统被激活,然而,患者并未出现高血压和心血管重塑,而是表现出与高血压相反的临床症状。Ang II的短期和长期信号传导仍是一个重要的研究课题,有助于阐明高血压病理生理学及其长期并发症的发病机制。Ang II的长期信号传导参与心血管-肾脏重塑和炎症反应的病理生理过程,其中RhoA/Rho激酶途径与NO系统之间的平衡起着关键作用。

方法与结果

在这篇简短的综述中,报告了我们在巴特综合征和吉特曼综合征研究中的结果。

结论

从这些研究中获得的信息可以阐明、证实或用于扩展导致高血压病理生理学及其长期并发症的生化机制,并可能提供更多机会来确定其他潜在的重要治疗靶点。

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