Ba B B, Iliadis A, Cano J P
INSERM U 278, Faculty of Pharmacy, Marseilles, France.
Ann Biomed Eng. 1989;17(6):633-46. doi: 10.1007/BF02367467.
A simultaneous consideration of plasma and urine data of unchanged drug and active metabolites, taking into account the metabolic process of the precursor, is described. The maximum likelihood principle was used to estimate parameters. This methodology is highly efficient in determining the contribution of the two main and active metabolites in the pharmacological response of ethyl loflazepate. It also may serve in the search for optimum dosage regimens in clinical practice.
本文描述了同时考虑未变化药物和活性代谢物的血浆和尿液数据，并考虑前体的代谢过程。采用最大似然原理来估计参数。该方法在确定两种主要活性代谢物对氯氟卓乙酯药理反应的贡献方面非常有效。它也可用于临床实践中寻找最佳给药方案。
