Schifter S
Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark.
Clin Endocrinol (Oxf). 1989 Mar;30(3):263-70. doi: 10.1111/j.1365-2265.1989.tb02234.x.
This investigation deals with the potential additional value of serum CGRP measurements as compared to calcitonin in screening for medullary carcinoma of the thyroid (MTC) in families with multiple endocrine neoplasia type 2 (MEN 2). Basal as well as pentagastrin-stimulated values for CGRP are evaluated in relation to the corresponding levels for calcitonin. Serum CGRP is within normal range in most family members with pathological calcitonin response to the pentagastrin stimulation test. Furthermore, these potentially affected family members do not respond to the pentagastrin stimulation test with an increase in CGRP. Pentagastrin stimulation tests performed in patients with manifest MTC affect the serum CGRP levels inconstantly and in two patients, with elevated basal level of CGRP, stimulation caused a release of calcitonin while concentrations of CGRP remained unaffected. We conclude that determination of serum CGRP adds no information to that of serum calcitonin in MEN 2 family screening for MTC.
本研究探讨了在2型多发性内分泌腺瘤病（MEN 2）家族中筛查甲状腺髓样癌（MTC）时，与降钙素相比，血清降钙素基因相关肽（CGRP）检测的潜在附加价值。评估了CGRP的基础值以及五肽胃泌素刺激值，并与相应的降钙素水平进行比较。在大多数对五肽胃泌素刺激试验有降钙素病理反应的家庭成员中，血清CGRP在正常范围内。此外，这些可能受影响的家庭成员对五肽胃泌素刺激试验没有CGRP升高的反应。对显性MTC患者进行的五肽胃泌素刺激试验对血清CGRP水平的影响不稳定，在两名CGRP基础水平升高的患者中，刺激导致降钙素释放，而CGRP浓度未受影响。我们得出结论，在MEN 2家族筛查MTC时，血清CGRP检测并未比血清降钙素检测提供更多信息。
