Ceci J D, Siracusa L D, Jenkins N A, Copeland N G
Mammalian Genetics Laboratory, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Maryland 21701.
Genomics. 1989 Nov;5(4):699-709. doi: 10.1016/0888-7543(89)90111-0.
We have constructed a 64-cM molecular genetic linkage map of mouse chromosome 4 using interspecific backcross animals derived from mating C57BL/6J and Mus spretus mice. Several proto-oncogenes and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lck, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or deletions on chromosome 4. New regions of synteny were defined between mouse chromosome 4 and human chromosomes 1 and 8; a region of homology was found between mouse chromosome 4 and human chromosome 6. This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes.
我们利用C57BL/6J小鼠与小家鼠杂交产生的种间回交动物构建了小鼠4号染色体的64厘摩分子遗传连锁图谱。几个原癌基因和病毒整合的常见位点已被定位到4号染色体的区域位置，包括Mos、Lyn、Jun、Lmyc、Lck、Fgr和Dsi-1。本研究中定位到4号染色体的其他基因座有Tsha、Mup-1、Rrm2-ps1、Ifa和Anf。将我们的定位数据与近交系定位数据进行比较，未发现4号染色体存在倒位或缺失的证据。确定了小鼠4号染色体与人类1号和8号染色体之间新的同线性区域；在小鼠4号染色体与人类6号染色体之间发现了一个同源区域。该连锁图谱将为鉴定小鼠和人类中可能参与各种疾病过程的同源基因提供一个框架。
