From the *Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital; †Division of Radiodiagnosis, Stellenbosch University and Tygerberg Hospital; ‡Department of Paediatrics, New-Somerset Hospital; and §Department of neuropathology, University of Cape Town, Cape Town, South Africa.
Pediatr Infect Dis J. 2015 Feb;34(2):214-8. doi: 10.1097/INF.0000000000000539.
Neurologic tuberculous pseudoabscesses that clinically progress despite conventional antituberculosis therapy may be responsive to adjuvant thalidomide, a potent tumor necrosis factor-α inhibitor. In this study, the addition of thalidomide provided substantial clinical benefit in the majority of patients, and magnetic resonance imaging evolution of lesions from early-stage "T2 bright" with edema to "T2 black" represented a marker of cure.
神经结核性假性脓肿，尽管经过常规抗结核治疗仍在临床进展，可能对辅助沙利度胺（一种有效的肿瘤坏死因子-α抑制剂）有反应。在这项研究中，沙利度胺的添加为大多数患者提供了显著的临床益处，并且病变的磁共振成像从早期的“T2 亮”伴水肿到“T2 黑”的演变代表了治愈的标志物。
