以氨基酸为拆分剂通过非对映体拆分制备光学纯δ-内酯。

Preparation of optically pure δ-lactones using diastereomeric resolution with amino acid as resolving agent.

作者信息

Shimotori Yasutaka, Hoshi Masayuki, Seki Syota, Osanai Takeshi, Okabe Hayato, Ikeda Yoshitaka, Miyakoshi Tetsuo

机构信息

Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology.

出版信息

J Oleo Sci. 2015;64(1):75-90. doi: 10.5650/jos.ess14124.

DOI:10.5650/jos.ess14124

PMID:25742924

Abstract

Synthesis of optically pure δ-lactones by diastereomeric resolution was investigated. Amino acid derivatives, which can be obtained at a relatively low cost, were used as resolving agents. Six optically pure δ-lactones were efficiently synthesized using Cbz-L-alanine without other expensive resolving agents. Both enantiomers of δ-lactone obtained had over 98% enantiomeric excesses. This diastereomeric resolution is very efficient for the preparation of optically pure δ-lactones.

摘要

研究了通过非对映体拆分合成光学纯δ-内酯。使用可以以相对低成本获得的氨基酸衍生物作为拆分剂。在没有其他昂贵拆分剂的情况下，使用Cbz-L-丙氨酸高效合成了六种光学纯δ-内酯。所得到的δ-内酯的两种对映体的对映体过量均超过98%。这种非对映体拆分对于制备光学纯δ-内酯非常有效。