痢疾志贺氏菌菌株Sd1617的基因组与代表性菌株在评估致病性方面的比较。
The genome of Shigella dysenteriae strain Sd1617 comparison to representative strains in evaluating pathogenesis.
作者信息
Vongsawan Ajchara A, Kapatral Vinayak, Vaisvil Benjamin, Burd Henry, Serichantalergs Oralak, Venkatesan Malabi M, Mason Carl J
机构信息
Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand
Igenbio Inc., Chicago, IL 60607, USA.
出版信息
FEMS Microbiol Lett. 2015 Mar;362(5). doi: 10.1093/femsle/fnv011. Epub 2015 Jan 28.
Abstract
We sequenced and analyzed Shigella dysenteriae strain Sd1617 serotype 1 that is widely used as model strain for vaccine design, trials and research. A combination of next-generation sequencing platforms and assembly yielded two contigs representing a chromosome size of 4.34 Mb and the large virulence plasmid of 177 kb. This genome sequence is compared with other Shigella genomes in order to understand gene complexity and pathogenic factors.
摘要
我们对痢疾志贺氏菌1617血清型菌株Sd1617进行了测序和分析，该菌株被广泛用作疫苗设计、试验和研究的模式菌株。结合使用下一代测序平台和组装技术，得到了两个重叠群，分别代表大小为4.34 Mb的染色体和177 kb的大毒力质粒。将该基因组序列与其他志贺氏菌基因组进行比较，以了解基因复杂性和致病因素。
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