Christopoulos Panagiotis F, Msaouel Pavlos, Koutsilieris Michael
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Goudi, Athens, Greece.
Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Mol Cancer. 2015 Feb 15;14:43. doi: 10.1186/s12943-015-0291-7.
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
胰岛素样生长因子-1（IGF-1）是乳腺中一种极为重要的促有丝分裂原。IGF-1与同源受体IGF-1R结合后，会触发一系列信号级联反应，从而引发增殖和抗凋亡事件。尽管许多相关的分子途径和细胞内级联反应仍有待阐明，但越来越多的证据表明IGF-1系统在乳腺癌的发生、发展和转移中起着重要作用。IGF-1是参与乳腺癌生长的主要信号通路的汇聚点。在本综述中，我们对IGF-1的功能、调节及其在乳腺恶性肿瘤中所起的作用进行了概述和简要更新。
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