Froidure Antoine, Pilette Charles
Institut de recherche expérimentale et clinique, Université catholique de Louvain, Walloon institute for excellence in lifesciences and biotechnology (WELBIO), avenue Hippocrate 54, boîte 1.54.04, 1200 Bruxelles, Belgique.
Institut de recherche expérimentale et clinique, Université catholique de Louvain, Walloon institute for excellence in lifesciences and biotechnology (WELBIO), avenue Hippocrate 54, boîte 1.54.04, 1200 Bruxelles, Belgique - Cliniques universitaires Saint-Luc, service de pneumologie, Bruxelles, Belgique.
Med Sci (Paris). 2015 Feb;31(2):151-8. doi: 10.1051/medsci/20153102011. Epub 2015 Mar 4.
The role of dendritic cells (DC) in the pathogenesis of allergic asthma and rhinitis has been highlighted for 15 years. In this review, we summarize key findings concerning DC function in airway allergy and focus on studies performed in human. DC coming from allergic patients have specific characteristics, including significant expression of high affinity receptor for IgE as well as a propensity for Th2 responses induction following priming with allergen and/or epithelial cytokines. Mechanistic data concerning this DC dysfunction in asthma also provide perspectives for innovating therapies.
树突状细胞（DC）在过敏性哮喘和鼻炎发病机制中的作用已被关注了15年。在本综述中，我们总结了关于DC在气道过敏中功能的关键发现，并着重介绍了在人体中进行的研究。来自过敏患者的DC具有特定特征，包括IgE高亲和力受体的显著表达，以及在用过敏原和/或上皮细胞因子启动后诱导Th2反应的倾向。关于哮喘中这种DC功能障碍的机制数据也为创新疗法提供了思路。
