Filimonov V G, Sheveleva G A, Chesnokova Ia M, Benediktova A B, Abubakirova A M
Akush Ginekol (Mosk). 1989 Sep(9):52-6.
The protective effect of the narcoanalgetics, viadril (hydroxydione sodium succinate) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy (the 19th day). The aforementioned rats were studied for the composition of the peripheral blood, their weight gain oxidative isoenzymes (LDH), pH and pO2 in the blood. Wilson's technique was used for the assessment of the fetal status. The offspring was studied with regard to the weight increment, the rate of postnatal mortality, behavioral reactions, etc. It was stated that viadril strengthened the resistance of pregnant animals to hypoxia and contributed to the alleviation of late sequela of posthypoxic changes in the fetus and newborn.
在146只妊娠晚期（第19天）模拟血液性缺氧的非近交系妊娠白色大鼠实验中，研究了腹腔注射剂量为5和20毫克/千克的麻醉镇痛药羟二酮琥珀酸钠（Viadril）的保护作用。对上述大鼠进行外周血成分、体重增加、氧化同工酶（乳酸脱氢酶）、血液pH值和氧分压的研究。采用威尔逊技术评估胎儿状况。对后代进行体重增加、产后死亡率、行为反应等方面的研究。结果表明，羟二酮琥珀酸钠增强了妊娠动物对缺氧的抵抗力，并有助于减轻胎儿和新生儿缺氧后变化的晚期后遗症。
