KO(t)Bu-I₂促进的 2-氧吲哚的氧化二聚反应：（±）-folicanthine 的全合成。
Oxidative dimerization of 2-oxindoles promoted by KO(t)Bu-I₂: total synthesis of (±)-folicanthine.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research, Bhopal - 462 066, MP, India.
出版信息
Org Lett. 2015 Mar 20;17(6):1373-6. doi: 10.1021/acs.orglett.5b00032. Epub 2015 Mar 6.
PMID:25745809
Abstract
A 'transition-metal-free' oxidative coupling of 2-oxindoles has been demonstrated in the presence of 1.2 equiv each of potassium tert-butoxide and iodine. The method yields a diverse range of structurally different homo- and heterodimerized 2-oxindoles bearing vicinal all-carbon quaternary centers of great synthetic importance. A radical-driven pathway has been tentatively proposed.
摘要
在 1.2 当量的叔丁醇钾和碘的存在下，实现了 2-氧吲哚的“无过渡金属”氧化偶联。该方法得到了具有相邻全碳季碳原子的结构多样的同型和异型 2-氧吲哚二聚体和多聚体，这些季碳原子具有重要的合成价值。初步提出了一种自由基驱动的反应途径。
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