Jeong Euy-Myoung, Dudley Samuel C
Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University.
Circ J. 2015;79(3):470-7. doi: 10.1253/circj.CJ-15-0064. Epub 2015 Feb 5.
Despite the growing number of patients affected, the understanding of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) is still poor. Clinical trials, largely based on successful treatments for systolic heart failure, have been disappointing, suggesting that HFpEF has a different pathology to that of systolic dysfunction. In this review, general concepts, epidemiology, diagnosis, and treatment of diastolic dysfunction are summarized, with an emphasis on new experiments suggesting that oxidative stress plays a crucial role in the pathogenesis of at least some forms of the disease. This observation has lead to potential new diagnostics and therapeutics for diastolic dysfunction and heart failure caused by diastolic dysfunction.
尽管受影响的患者数量不断增加，但对舒张功能障碍和射血分数保留的心力衰竭（HFpEF）的了解仍然不足。主要基于收缩性心力衰竭成功治疗方法的临床试验令人失望，这表明HFpEF的病理与收缩功能障碍不同。在这篇综述中，总结了舒张功能障碍的一般概念、流行病学、诊断和治疗，重点介绍了新的实验，这些实验表明氧化应激在至少某些形式的该疾病发病机制中起关键作用。这一观察结果为舒张功能障碍及由舒张功能障碍引起的心力衰竭带来了潜在的新诊断方法和治疗手段。
