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一项有组织的肠道管理计划在儿童严重慢性便秘管理中的有效性。

Effectiveness of an organized bowel management program in the management of severe chronic constipation in children.

作者信息

Russell Katie W, Barnhart Douglas C, Zobell Sarah, Scaife Eric R, Rollins Michael D

机构信息

University of Utah, Division of Pediatric Surgery, Primary Children's Hospital, 100 North Mario Capecchi Drive, Suite 2600, Salt Lake City, UT 84113.

University of Utah, Division of Pediatric Surgery, Primary Children's Hospital, 100 North Mario Capecchi Drive, Suite 2600, Salt Lake City, UT 84113.

出版信息

J Pediatr Surg. 2015 Mar;50(3):444-7. doi: 10.1016/j.jpedsurg.2014.08.006. Epub 2014 Dec 6.

Abstract

BACKGROUND

Chronic constipation is a common problem in children. The cause of constipation is often idiopathic, when no anatomic or physiologic etiology can be identified. In severe cases, low dose laxatives, stool softeners and small volume enemas are ineffective. The purpose of this study was to assess the effectiveness of a structured bowel management program in these children.

METHODS

We retrospectively reviewed children with chronic constipation without a history of anorectal malformation, Hirschsprung's disease or other anatomical lesions seen in our pediatric colorectal center. Our bowel management program consists of an intensive week where treatment is assessed and tailored based on clinical response and daily radiographs. Once a successful treatment plan is established, children are followed longitudinally. The number of patients requiring hospital admission during the year prior to and year after initiation of bowel management was compared using Fisher's exact test.

RESULTS

Forty-four children with refractory constipation have been followed in our colorectal center for greater than a year. Fifty percent had at least one hospitalization the year prior to treatment for obstructive symptoms. Children were treated with either high-dose laxatives starting at 2mg/kg of senna or enemas starting at 20ml/kg of normal saline. Treatment regimens were adjusted based on response to therapy. The admission rate one-year after enrollment was 9% including both adherent and nonadherent patients. This represents an 82% reduction in hospital admissions (p<0.001).

CONCLUSIONS

Implementation of a structured bowel management program similar to that used for children with anorectal malformations, is effective and reduces hospital admissions in children with severe chronic constipation.

摘要

背景

慢性便秘是儿童常见问题。当无法确定解剖学或生理学病因时,便秘原因通常为特发性。在严重病例中,低剂量泻药、大便软化剂和小容量灌肠剂无效。本研究目的是评估结构化肠道管理方案对这些儿童的有效性。

方法

我们回顾性分析了在我院小儿结直肠中心就诊的无肛门直肠畸形、先天性巨结肠病或其他解剖学病变病史的慢性便秘儿童。我们的肠道管理方案包括为期一周的强化治疗,在此期间根据临床反应和每日X光片评估并调整治疗方案。一旦确立成功的治疗方案,就对儿童进行长期随访。使用Fisher精确检验比较肠道管理开始前一年和开始后一年需要住院治疗的患者数量。

结果

我院结直肠中心对44例难治性便秘儿童进行了一年多的随访。50%的儿童在治疗前一年因梗阻症状至少住院一次。儿童接受起始剂量为2mg/kg番泻叶的高剂量泻药或起始剂量为20ml/kg生理盐水的灌肠治疗。根据治疗反应调整治疗方案。入组一年后的住院率为9%,包括依从和不依从的患者。这意味着住院率降低了82%(p<0.001)。

结论

实施类似于用于肛门直肠畸形儿童的结构化肠道管理方案,对严重慢性便秘儿童有效且可降低住院率。

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