Sander Stephanie A, Van Hall Alexandra K, Morrow Janet R
Department of Chemistry, University at Buffalo, the State University of New York, Amherst, New York 14260, United States.
Inorg Chem. 2015 Apr 6;54(7):3084-6. doi: 10.1021/ic503074p. Epub 2015 Mar 9.
DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn(2+) complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn(2+) complex or by free ZnCl2 and a macrocyclic ligand. The switch is selective for Zn(2+) over biologically relevant transition-metal ions including Cu(2+) and Fe(2+). The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.
在与小分子结合时二级结构会发生巨大变化的DNA序列是分子开关的基础。在此，我们报道了一种锌（II）配合物，它能促使完全互补的DNA双螺旋转变为DNA发夹结构。这种构象转换可由分离的锌（II）配合物或游离的氯化锌和大环配体来促进。该转换对锌（II）具有选择性，优于包括铜（II）和铁（II）在内的生物相关过渡金属离子。这种双配体/DNA开关是一种可能会提高金属离子传感应用选择性的方法。
