用于疫苗、基因治疗载体和噬菌体生产的下游加工及基于色谱的分析方法。
Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages.
作者信息
Kramberger Petra, Urbas Lidija, Štrancar Aleš
机构信息
a BIA Separations ; Ajdovščina , Slovenia.
出版信息
Hum Vaccin Immunother. 2015;11(4):1010-21. doi: 10.1080/21645515.2015.1009817.
Abstract
Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production.
摘要
纳米复合物（病毒、病毒样颗粒、噬菌体）的下游处理具有起始材料复杂、可供选择的纯化方法众多、为最终产品设定框架的法规以及上游和下游监测的分析方法等特点。本综述概述了纳米复合物下游面临的挑战以及基于色谱的分析方法，以有效监测纳米复合物的生产。
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