Sturgill James F, Isaacson Jeffry S
Center for Neural Circuits and Behavior, Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Nat Neurosci. 2015 Apr;18(4):531-5. doi: 10.1038/nn.3971. Epub 2015 Mar 9.
Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons.
多种类型的局部γ-氨基丁酸能中间神经元塑造了感觉信息的皮质表征。在此，我们展示了表达生长抑素的中间神经元（SOM细胞）如何在小鼠嗅觉皮质中对气味编码发挥作用。我们发现，气味调谐的SOM细胞通过一种纯粹的减法运算来调节主细胞，该运算与气味的特性或强度无关。这种运算增强了气味诱发活动的显著性，而不改变皮质气味调谐。SOM细胞抑制主细胞和快速放电中间神经元，这表明减法抑制反映了多类中间神经元之间的相互作用。
