脑岛背侧后部在人类疼痛中起基本作用。
The dorsal posterior insula subserves a fundamental role in human pain.
作者信息
Segerdahl Andrew R, Mezue Melvin, Okell Thomas W, Farrar John T, Tracey Irene
机构信息
1] Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK. [2] Nuffield Division of Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
出版信息
Nat Neurosci. 2015 Apr;18(4):499-500. doi: 10.1038/nn.3969. Epub 2015 Mar 9.
Abstract
Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.
摘要
几个脑区与人类的疼痛体验有关，但尚无一个被证明对疼痛具有特异性。我们利用动脉自旋标记定量灌注成像和一种新开发的程序来确定背侧后岛叶（dpIns）在疼痛中的特定作用。动物的示踪研究确定了一个类似区域对伤害感受至关重要，这表明dpIns是其人类同源物，因此是一个潜在的治疗靶点。
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