Barthel Henryk, Seibyl John, Sabri Osama
Department of Nuclear Medicine, Leipzig University, Liebigstr. 11, 04103 Leipzig, Germany.
Expert Rev Neurother. 2015 Apr;15(4):395-406. doi: 10.1586/14737175.2015.1023296. Epub 2015 Mar 9.
PET is a non-invasive imaging technique which allows the visualization and quantification of molecular processes, offering sensitive and early disease detection. Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to memory loss and other functional impairments. By employing different tracers targeting neurodegeneration, amyloid and tau aggregates, cholinergic neurotransmission, neuroinflammation and other processes, PET imaging enhances our understanding of the potential triggers of AD, the chronology of molecular events in AD, the detection of early AD, differentiation of AD dementia from other dementia disorders and the development of better drugs to treat AD. As such, PET imaging at different disease stages (asymptomatic, prodromal and dementia stages) is on its way to becoming a valuable routine clinical biomarker and a drug testing and research tool in AD.
正电子发射断层扫描（PET）是一种非侵入性成像技术，可实现分子过程的可视化和定量分析，有助于进行敏感且早期的疾病检测。阿尔茨海默病（AD）是一种进行性神经退行性疾病，会导致记忆力丧失和其他功能障碍。通过使用针对神经退行性变、淀粉样蛋白和tau蛋白聚集体、胆碱能神经传递、神经炎症及其他过程的不同示踪剂，PET成像增进了我们对AD潜在触发因素、AD分子事件发生顺序、早期AD检测、AD痴呆与其他痴呆症的鉴别以及研发更好的AD治疗药物的理解。因此，在不同疾病阶段（无症状、前驱和痴呆阶段）进行的PET成像正逐渐成为AD中一种有价值的常规临床生物标志物以及药物测试和研究工具。
