Wang Xinzhi, Zhang Luyong, Jiang Zhenzhou
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, People's Republic of China.
Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, People's Republic of China.
J Appl Toxicol. 2015 Jul;35(7):695-700. doi: 10.1002/jat.3115. Epub 2015 Mar 6.
Drug-induced liver injury (DILI) leads to a large burden on the healthcare system due to its potential morbidity and mortality. The key for predicting and preventing DILI is to understand the underlying mechanisms. Hepatic inflammation is one of the most common features of DILI. The inflammation can be attributed to the innate immune response. The adaptive immune system is also affected by the innate immune response resulting in liver damage. T-helper cells are important regulators of acquired immunity. T-helper cell-mediated immune responses play pivotal roles in the pathogenesis of a variety of liver disorders. This review summarizes recent advances in the T-helper cell-mediated factors in DILI and potential mechanisms, which may lead to a better understanding of DILI.
药物性肝损伤（DILI）因其潜在的发病率和死亡率给医疗保健系统带来了巨大负担。预测和预防DILI的关键在于了解其潜在机制。肝脏炎症是DILI最常见的特征之一。这种炎症可归因于先天免疫反应。适应性免疫系统也受到先天免疫反应的影响，从而导致肝损伤。辅助性T细胞是获得性免疫的重要调节因子。辅助性T细胞介导的免疫反应在多种肝脏疾病的发病机制中起关键作用。本综述总结了DILI中辅助性T细胞介导的因素及潜在机制的最新进展，这可能有助于更好地理解DILI。
