Chang Dalu, Gu Yang, Shen Qilong
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China).
Chemistry. 2015 Apr 13;21(16):6074-8. doi: 10.1002/chem.201500551. Epub 2015 Mar 6.
Pd-catalyzed difluoromethylation of di-, tri- or tetra-substituted vinyl bromides, triflates, tosylates and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes.
描述了在温和条件下钯催化二取代、三取代或四取代的乙烯基溴化物、三氟甲磺酸酯、对甲苯磺酸酯和九氟丁磺酸酯的二氟甲基化反应。该反应能耐受多种官能团，如溴、氯、氟、酯、胺、腈和保护的羰基，从而为制备二氟甲基化烯烃提供了一条通用途径。
