Tutton P J, Barkla D H
Department of Anatomy, Monash University, Clayton, Victoria, Australia.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(6):349-52. doi: 10.1007/BF02899100.
The intestinal mucosa receives an adrenergic innervation for which there is no commonly accepted function. However, in recent years, cell kinetic studies have raised the possibility that this innervation may be an important regulator of crypt cell proliferation. The effects of noradrenaline released from adrenergic nerves is terminated principally by re-uptake of the amine into the nerve and this process can be inhibited by the antidepressant drug, desipramine. In this report desipramine is shown to accelerate crypt cell proliferation in intact, but not in chemically sympathectomized rats, thus adding support to the notion that regulation of crypt cell division is an important function of the sympathetic nervous system.
肠黏膜接受肾上腺素能神经支配，但其功能尚无普遍认可的定论。然而，近年来细胞动力学研究提出一种可能性，即这种神经支配可能是隐窝细胞增殖的重要调节因子。肾上腺素能神经释放的去甲肾上腺素的作用主要通过胺类物质重新摄取回神经而终止，而这一过程可被抗抑郁药物地昔帕明抑制。在本报告中，地昔帕明在完整大鼠而非化学去交感神经大鼠中可加速隐窝细胞增殖，从而支持了隐窝细胞分裂的调节是交感神经系统的一项重要功能这一观点。
