Pu Zhaoxia, Wang Yao, Zhang Ying, Huang Jing, Hong Yurong, He Huiliao, Liu Chunmei, Chen Shuyuan, Grayburn Paul A, Huang Pintong
Department of Ultrasound, the Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang 310009, China.
Department of Ultrasound, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, China.
Sci Rep. 2015 Mar 10;5:8956. doi: 10.1038/srep08956.
The purpose of this study was to investigate the effect of the angiogenesis inhibitor Endostar on carotid plaque neovascularization in patients with non-small cell lung cancer (NSCLC) using contrast-enhanced ultrasound (CEUS). Ninety-one patients who had NSCLC with soft carotid plaques were selected for treatment either with the NP regimen (vinorelbine + cisplatin) (43 patients) or with the ENP regimen (Endostar + NP) (48 patients). Plaque thickness and neovascularization of the plaque were assessed before and at 1 month after treatment using CEUS. Enhanced intensity (EI) of CEUS was used for quantification of plaque neovascularization. There was no significant changes in any group in thickness of plaque between recruitment and 1 month after treatment (P > 0.05 for all). There was no significant change in the EI of plaque in the controls or NP groups at 1 month after treatment (P > 0.05), while EI in the ENP group was significantly reduced at 1 month after treatment (P < 0.01) and significantly lower than that in the controls or NP group at 1 month after treatment (P < 0.001 both). This study indicates that carotid soft plaque neovascularization in patients with NSCLC can be reduced by anti-angiogenesis treatment.
本研究旨在采用超声造影（CEUS）探讨血管生成抑制剂恩度对非小细胞肺癌（NSCLC）患者颈动脉斑块新生血管形成的影响。选取91例患有NSCLC且伴有颈动脉软斑块的患者，分别采用NP方案（长春瑞滨+顺铂）治疗（43例）或ENP方案（恩度+NP）治疗（48例）。在治疗前及治疗后1个月，使用CEUS评估斑块厚度及斑块新生血管形成情况。采用CEUS的增强强度（EI）对斑块新生血管形成进行定量分析。在入组时及治疗后1个月，各组斑块厚度均无显著变化（所有P>0.05）。治疗后1个月，对照组和NP组的斑块EI无显著变化（P>0.05），而ENP组治疗后1个月EI显著降低（P<0.01），且显著低于治疗后1个月的对照组和NP组（两者P<0.001）。本研究表明，抗血管生成治疗可减少NSCLC患者颈动脉软斑块新生血管形成。
