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Initial experience of use of tolvaptan in critically ill patients with fluid overload.

作者信息

Ruiz-Ramos J, Gordon M, Cortes M A, Broch M J, Ramirez P

机构信息

Intensive Care Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

出版信息

J Clin Pharm Ther. 2015 Jun;40(3):339-41. doi: 10.1111/jcpt.12255. Epub 2015 Mar 6.

DOI:10.1111/jcpt.12255
PMID:25753481
Abstract

WHAT IS KNOWN AND OBJECTIVE

Positive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload.

CASE SUMMARY

Six patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of -2362 (-485 to -3447) mL. At the end of treatment, median fluid balance variation was -9080 (-26,784 to -4395) mL.

WHAT IS NEW AND CONCLUSION

Tolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.

摘要

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