磁共振成像（MRI）联合正电子发射断层显像（PET）/CT在舌鳞状细胞癌诊断及术前分期中的应用价值

Application value of MRI combined with positron emission tomography (PET)/CT in diagnosis and preoperative staging of tongue squamous cell carcinoma.

作者信息

Chen Wenbo, Zhang Chunxing, Zhang Shuixing, Liang Long, Zhang Bin, Liu Chunling, Zhang Zhonglin, Liang Changhong

机构信息

Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, Guangdong, China; Graduate College, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

J Med Imaging Radiat Oncol. 2015 Apr;59(2):170-8. doi: 10.1111/1754-9485.12282. Epub 2015 Mar 5.

DOI:10.1111/1754-9485.12282

PMID:25753588

Abstract

INTRODUCTION

This study aimed to compare and analyse the findings of tongue squamous cell carcinoma (TSCC) on MRI and positron emission tomography (PET)/CT and explore the diagnostic utility of combined MRI-PET/CT in the diagnosis and preoperative staging of TSCC.

METHODS

A prospective analysis of MRI and PET/CT data in 18 TSCC cases was performed. Cases were comprehensively staged on MRI and PET/CT preoperatively according to American Joint Committee on Cancer (AJCC) staging criteria and confirmed by pathological results.

RESULTS

The highest and lowest sensitivities of preoperative AJCC staging I-IV using MRI alone, PET/CT alone and combined MRI-PET/CT were 100.0%, 100.0% and 100.0% (stage II) and 50.4%, 55.6% and 55.6% (stage I), respectively. The highest specificities were 100.0%, 100.0% and 100.0% (stage II), and the highest correct rates were 100.0%, 96.5% and 100.0% (stage II). Compared with the postoperative pathological staging, preoperative staging showed no significant difference for stages I-II and IV (P > 0.05); however, stage III showed a significant difference (P < 0.05). When combined MRI-PET/CT was compared with MRI alone in the accuracy of preoperative TSCC staging, there was no significant difference for stages I-III (P > 0.05), but there was a significant difference for stage IV (P < 0.05).

CONCLUSIONS

Combined MRI and PET/CT could serve as an important tool for the accurate diagnosis and preoperative staging of TSCC and could improve the accuracy of preoperative TSCC staging.

摘要

引言

本研究旨在比较和分析舌鳞状细胞癌（TSCC）在磁共振成像（MRI）和正电子发射断层扫描（PET）/CT上的表现，并探讨联合MRI-PET/CT在TSCC诊断及术前分期中的应用价值。

方法

对18例TSCC患者的MRI和PET/CT数据进行前瞻性分析。术前根据美国癌症联合委员会（AJCC）分期标准，通过MRI和PET/CT对病例进行综合分期，并经病理结果证实。

结果

单独使用MRI、单独使用PET/CT以及联合MRI-PET/CT进行术前AJCC I-IV期分期时，最高敏感性分别为100.0%、100.0%和100.0%（II期），最低敏感性分别为50.4%、55.6%和55.6%（I期）。最高特异性分别为100.0%、100.0%和100.0%（II期），最高正确率分别为100.0%、96.5%和100.0%（II期）。与术后病理分期相比，I-II期和IV期术前分期差异无统计学意义（P>0.05）；然而，III期差异有统计学意义（P<0.05）。联合MRI-PET/CT与单独MRI在术前TSCC分期准确性方面比较，I-III期差异无统计学意义（P>0.05），但IV期差异有统计学意义（P<0.05）。