Chen Wenbo, Zhang Chunxing, Zhang Shuixing, Liang Long, Zhang Bin, Liu Chunling, Zhang Zhonglin, Liang Changhong
Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, Guangdong, China; Graduate College, Southern Medical University, Guangzhou, Guangdong, China.
J Med Imaging Radiat Oncol. 2015 Apr;59(2):170-8. doi: 10.1111/1754-9485.12282. Epub 2015 Mar 5.
This study aimed to compare and analyse the findings of tongue squamous cell carcinoma (TSCC) on MRI and positron emission tomography (PET)/CT and explore the diagnostic utility of combined MRI-PET/CT in the diagnosis and preoperative staging of TSCC.
A prospective analysis of MRI and PET/CT data in 18 TSCC cases was performed. Cases were comprehensively staged on MRI and PET/CT preoperatively according to American Joint Committee on Cancer (AJCC) staging criteria and confirmed by pathological results.
The highest and lowest sensitivities of preoperative AJCC staging I-IV using MRI alone, PET/CT alone and combined MRI-PET/CT were 100.0%, 100.0% and 100.0% (stage II) and 50.4%, 55.6% and 55.6% (stage I), respectively. The highest specificities were 100.0%, 100.0% and 100.0% (stage II), and the highest correct rates were 100.0%, 96.5% and 100.0% (stage II). Compared with the postoperative pathological staging, preoperative staging showed no significant difference for stages I-II and IV (P > 0.05); however, stage III showed a significant difference (P < 0.05). When combined MRI-PET/CT was compared with MRI alone in the accuracy of preoperative TSCC staging, there was no significant difference for stages I-III (P > 0.05), but there was a significant difference for stage IV (P < 0.05).
Combined MRI and PET/CT could serve as an important tool for the accurate diagnosis and preoperative staging of TSCC and could improve the accuracy of preoperative TSCC staging.
本研究旨在比较和分析舌鳞状细胞癌（TSCC）在磁共振成像（MRI）和正电子发射断层扫描（PET）/CT上的表现，并探讨联合MRI-PET/CT在TSCC诊断及术前分期中的应用价值。
对18例TSCC患者的MRI和PET/CT数据进行前瞻性分析。术前根据美国癌症联合委员会（AJCC）分期标准，通过MRI和PET/CT对病例进行综合分期，并经病理结果证实。
单独使用MRI、单独使用PET/CT以及联合MRI-PET/CT进行术前AJCC I-IV期分期时，最高敏感性分别为100.0%、100.0%和100.0%（II期），最低敏感性分别为50.4%、55.6%和55.6%（I期）。最高特异性分别为100.0%、100.0%和100.0%（II期），最高正确率分别为100.0%、96.5%和100.0%（II期）。与术后病理分期相比，I-II期和IV期术前分期差异无统计学意义（P>0.05）；然而，III期差异有统计学意义（P<0.05）。联合MRI-PET/CT与单独MRI在术前TSCC分期准确性方面比较，I-III期差异无统计学意义（P>0.05），但IV期差异有统计学意义（P<0.05）。
联合MRI和PET/CT可作为TSCC准确诊断及术前分期的重要工具，可提高TSCC术前分期的准确性。
