Eriksen Willy, Sundet Jon Martin, Tambs Kristian
Division of Mental Health, Norwegian Institute of Public Health, 0403, Oslo, Norway.
Department of Psychology, University of Oslo, 0317, Oslo, Norway.
Am J Hum Biol. 2015 Jul-Aug;27(4):564-9. doi: 10.1002/ajhb.22689. Epub 2015 Mar 7.
The aim of this birth cohort study was to determine the relationship between birth weight and the risk of overweight in young adulthood.
Data from the Medical Birth Registry of Norway were linked with register data from the National Conscript Service. This study used data on the 348,800 males who were born at term in single births in Norway during 1967 to 1984, and who were examined at the mandatory military conscription (98% were examined the year they turned 18 or 19 years of age). Sibling comparisons were conducted in the 11,865 sibships of two or more full brothers in which at least one brother was overweight (body mass index ≥25.0 kg/m(2) ) and at least one brother was not overweight.
When all the men in the study population were compared with each other there was a "J"-shaped association between birth weight and the adjusted odds of overweight. When the men were compared with their brothers, the adjusted odds of overweight increased in an exponential way (linearly in logit) over the entire range of the birth weight scale. A within-family difference of 100 g in birth weight was associated with a within-family difference of 3.5% (99% confidence interval: 2.5-4.6) in the odds of overweight.
There is a positive within-family association between birth weight and the odds of overweight in young Norwegian men born at term.
本队列研究旨在确定出生体重与青年期超重风险之间的关系。
挪威医学出生登记处的数据与国家征兵服务处的登记数据相链接。本研究使用了1967年至1984年期间在挪威足月单胎出生、并在义务兵役体检时接受检查的348,800名男性的数据（98%的男性在年满18或19岁的当年接受了检查）。在至少有一个兄弟超重（体重指数≥25.0 kg/m²）且至少有一个兄弟不超重的11,865个有两个或更多亲兄弟的家庭中进行了兄弟间比较。
当对研究人群中的所有男性进行相互比较时，出生体重与超重调整后的比值比呈“J”形关联。当将这些男性与其兄弟进行比较时，在整个出生体重范围内，超重调整后的比值比呈指数方式增加（对数线性）。出生体重在家庭内部相差100克，与超重比值比在家庭内部相差3.5%（99%置信区间：2.5 - 4.6）相关。
在挪威足月出生的青年男性中，出生体重与超重比值比在家庭内部存在正相关。
