Xu Tongyu, Alper Howard
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario Canada, K1N 6N5.
Org Lett. 2015 Mar 20;17(6):1569-72. doi: 10.1021/acs.orglett.5b00452. Epub 2015 Mar 10.
N-Fused heterocycles can be easily synthesized by palladium-catalyzed dearomatizing carbonylation using 1,3-bis(diisobutylphosphino)propane (DIBPP) as the ligand. Pyrido[2,1-b]quinazolin-11-ones were obtained from N-(2-bromophenyl)pyridine-2-amines in up to quantitative yield and dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones from 3-bromo-N-(pyridine-2-yl)pyridine-2-amines in up to 84% yield. The cyclocarbonylation can be also realized without isolation of compound 1 and additional palladium catalyst.
使用1,3-双（二异丁基膦基）丙烷（DIBPP）作为配体，通过钯催化的去芳构化羰基化反应可以轻松合成N-稠合杂环。从N-（2-溴苯基）吡啶-2-胺中获得吡啶并[2,1-b]喹唑啉-11-酮，产率高达定量，从3-溴-N-（吡啶-2-基）吡啶-2-胺中获得二吡啶并[1,2-a：2'，3'-d]嘧啶-5-酮，产率高达84%。环羰基化反应也可以在不分离化合物1和额外钯催化剂的情况下实现。
