Santos Ana Luisa
CIAS and Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.
Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S109-11. doi: 10.1016/j.tube.2015.02.014. Epub 2015 Feb 13.
Tuberculosis (TB) may be an acute or chronic infection of bone and/or soft tissues. Nevertheless, human skeletons only registered a small percentage of those cases. This work aims to explore data from morbidity and mortality of individuals who contracted or died of TB after Koch bacillus discovery and before the development of antibiotics, using this information to interpret the scarcity of evidences detectable by paleopathological studies. To fulfill these goals, the Coimbra University Hospital and Coimbra Municipality Cemetery records from 1919 to 1928 were analyzed. As expected, pulmonary TB was the most common form of the diseases, both at hospital admission (43.7%, n=904) and as cause of death of the individuals inhumed, especially after the age of 10 years. In children under 10 years, meningeal TB was the more common form. Pott's diseases represented only 4.7% (n=98) of the hospital admission due to TB and 0.7% (n=8) of the TB deaths at the cemetery. However, in paleopathology the macroscopic evidence of TB comes mainly from Pott's disease. Documented skeletons shows that new bone on visceral surfaces of ribs can occurs in other diseases besides pulmonary TB but its presence can be also use as an indicative of possible TB infection.
结核病（TB）可能是骨骼和/或软组织的急性或慢性感染。然而，人类骨骼中记录的此类病例仅占一小部分。这项研究旨在探究在发现结核杆菌后至抗生素研发之前感染或死于结核病的个体的发病率和死亡率数据，利用这些信息来解释古病理学研究中可检测到的证据稀缺的原因。为实现这些目标，对科英布拉大学医院和科英布拉市公墓1919年至1928年的记录进行了分析。不出所料，肺结核是最常见的疾病形式，无论是在医院入院时（43.7%，n = 904），还是在埋葬个体的死因中，尤其是在10岁以后。在10岁以下的儿童中，结核性脑膜炎是更常见的形式。波特氏病仅占因结核病入院病例的4.7%（n = 98），占公墓中结核病死亡病例的0.7%（n = 8）。然而，在古病理学中，结核病的宏观证据主要来自波特氏病。有记录的骨骼显示，肋骨内脏表面的新骨除了肺结核外，也可能出现在其他疾病中，但其存在也可作为可能感染结核病的一个指标。
