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[外科取栓术及体外膜肺氧合治疗在大面积肺栓塞治疗中的作用——综述]

[The role of surgical embolectomy and extracorporeal membrane oxygen therapy in the treatment of massive pulmonary embolism - a review].

作者信息

Šimek M, Hutyra M, Gwozdziewicz M, Fluger I, Steriovský A, Konečný J

出版信息

Rozhl Chir. 2015 Mar;94(3):103-10.

Abstract

Acute massive pulmonary embolism remains potentially lethal with mortality varying between 2553%. In the thrombolytic era, surgical pulmonary embolectomy is deemed as a rescue approach for patients with absolute contraindication of thrombolysis or its failure. However, close interdisciplinary cooperation, meticulous choice of optimal reperfusion strategy, standardization of surgical approach, and mainly the inclusion of mechanical circulatory support into the treatment algorithm have led to a drop in in-hospital mortality below 10% in the last 10 years. Nevertheless, cardiac arrest and refractory cardiogenic shock still remain independent risk factors of death with mortality exceeding 70%. Extracorporeal membrane oxygen therapy provides rapid circulatory support, end-organ perfusion and oxygenation which are essential for right-sided obstruction haemodynamic. Subsequently, optimal reperfusion strategy can be chosen or patients may be transported for it. The review highlights the contemporary role of surgical pulmonary embolectomy and extracorporeal membrane oxygen therapy in the treatment algorithm for acute massive pulmonary embolism, summarising current perspectives on the indications and contraindications for these treatment strategies and their results.Key words: massive pulmonary embolism - surgical pulmonary embolectomy - extracorporeal membrane oxygen therapy.

摘要

急性大面积肺栓塞仍然具有潜在致死性,死亡率在25%至53%之间。在溶栓时代,外科肺动脉血栓切除术被视为溶栓绝对禁忌或溶栓失败患者的一种挽救方法。然而,紧密的多学科合作、精心选择最佳再灌注策略、手术方法的标准化,以及主要将机械循环支持纳入治疗方案,使得过去10年住院死亡率降至10%以下。尽管如此,心脏骤停和难治性心源性休克仍然是独立的死亡危险因素,死亡率超过70%。体外膜肺氧合治疗可提供快速循环支持、终末器官灌注和氧合,这对于右侧梗阻性血流动力学至关重要。随后,可以选择最佳再灌注策略,或者患者可以为此而转运。本文综述强调了外科肺动脉血栓切除术和体外膜肺氧合治疗在急性大面积肺栓塞治疗方案中的当代作用,总结了这些治疗策略的适应证、禁忌证及其结果的当前观点。关键词:大面积肺栓塞 - 外科肺动脉血栓切除术 - 体外膜肺氧合治疗

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