Bioisosteric transformation of H1-antihistaminic benzimidazole derivatives.
作者信息
Iemura R, Hori M, Saito T, Ohtaka H
出版信息
Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2723-6. doi: 10.1248/cpb.37.2723.
PMID:2575462
Abstract
With the aim of obtaining new H1-antihistaminic agents, transformations of previously reported antihistaminic benzimidazoles were performed on the basis of the concept of bioisosterism. Among the compounds prepared, imidazo[4,5-b]pyridine (8) and 4(3H)-quinazolinone (11) exhibited significant H1-antihistaminic activity.
摘要
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