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原发性静脉疾病患者中腔内激光消融功能不全穿通静脉和大隐静脉的效果。

The effect of endovenous laser ablation of incompetent perforating veins and the great saphenous vein in patients with primary venous disease.

机构信息

Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaouju Rd, Shanghai, 200011, China.

Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaouju Rd, Shanghai, 200011, China.

出版信息

Eur J Vasc Endovasc Surg. 2015 May;49(5):574-80. doi: 10.1016/j.ejvs.2015.01.013. Epub 2015 Mar 5.

Abstract

OBJECTIVE/BACKGROUND: This study aimed to investigate the clinical results and fate of incompetent perforating veins (IPVs) following treatment of superficial venous insufficiency, with or without endovenous laser ablation (EVLA) of IPVs.

METHODS

A retrospective analysis of patients with primary venous insufficiency (PVI) was conducted in a single institution from January, 2010 to December, 2011. IPVs were found in 311 patients (376 limbs). Among these, 132 patients (156 limbs) were treated with EVLA of IPVs and varicose vein surgery, and the remaining 179 patients (220 limbs) were treated with varicose vein surgery alone and served as controls. The fate of the IPVs, complications and clinical results were evaluated.

RESULTS

The technical success rate of EVLA of IPVs was 100%. There was no statistical difference in complications between the two groups. At 1 year follow up, 68 perforators were recanalized and still incompetent in the EVLA treated IPV group compared with 437 incompetent perforators in the untreated IPV group (18.7% vs. 92.6%; p < .001). A faster median ulcer healing time (1.40 months) was found in the EVLA treated IPV group (95% confidence interval [CI] 1.15-1.66 vs. 3.30 months [95% CI 2.50-4.10]; p = .001), even though no statistical difference in the 12 month ulcer healing rate was observed between the two groups (p = .584). There were no significant differences between the two groups for varicose vein recurrence rates or changes in the Venous Clinical Severity Score (VCSS).

CONCLUSION

EVLA was safe and effective in reducing the number of IPVs in PVI. However, the addition of IPV EVLA had no effect on ulcer healing rate, VCSS or varicose vein recurrence at 1 year follow up.

摘要

目的/背景:本研究旨在探讨单纯治疗浅静脉功能不全(PVI)与联合腔内激光消融(EVLA)治疗 PVI 后功能不全穿通静脉(IPV)的临床效果和结局。

方法

在一家医疗机构,回顾性分析了 2010 年 1 月至 2011 年 12 月期间患有原发性静脉功能不全(PVI)的患者。311 例患者(376 条肢体)中发现有 IPV。其中 132 例患者(156 条肢体)接受 EVLA 联合静脉切除术治疗,其余 179 例患者(220 条肢体)仅接受静脉切除术治疗作为对照。评估 IPV 的结局、并发症和临床结果。

结果

EVLA 治疗 IPV 的技术成功率为 100%。两组并发症发生率无统计学差异。在 1 年随访时,EVLA 治疗的 IPV 组有 68 个穿通支再通且仍功能不全,而未治疗的 IPV 组有 437 个功能不全的穿通支(18.7%比 92.6%;p<0.001)。EVLA 治疗的 IPV 组溃疡愈合时间中位数更快(1.40 个月,95%置信区间[CI] 1.15-1.66 比 3.30 个月[95%CI 2.50-4.10];p=0.001),尽管两组 12 个月溃疡愈合率无统计学差异(p=0.584)。两组静脉曲张复发率或静脉临床严重程度评分(VCSS)变化无显著差异。

结论

EVLA 治疗 PVI 时安全有效,可减少 IPV 数量。然而,在 1 年随访时,联合 EVLA 治疗 IPV 对溃疡愈合率、VCSS 或静脉曲张复发无影响。

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