Is low dose hydroxyurea the solution to the global epidemic of sickle cell disease?
作者信息
Strouse John J
机构信息
Department of Pediatrics, Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
Pediatr Blood Cancer. 2015 Jun;62(6):929-30. doi: 10.1002/pbc.25471. Epub 2015 Mar 8.
Abstract
摘要
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Is low dose hydroxyurea the solution to the global epidemic of sickle cell disease?低剂量羟基脲是解决镰状细胞病全球流行问题的方法吗？
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Low and fixed dose of hydroxyurea is effective and safe in patients with HbSβ(+) thalassemia with IVS1-5(G→C) mutation.低剂量固定剂量的羟基脲对患有IVS1-5（G→C）突变的HbSβ（+）地中海贫血患者有效且安全。
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Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.全球、地区和国家按年龄、性别划分的 240 种死因的全死因和特定死因死亡率，1990-2013 年：2013 年全球疾病负担研究的系统分析。
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Reproductive issues in sickle cell disease.镰状细胞病的生殖问题。
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The effect of hydroxyurea on compound heterozygotes for sickle cell-hemoglobin D-Punjab--a single centre experience in eastern India.羟基脲治疗镰状细胞-血红蛋白 D-旁遮普双重杂合子的效果：印度东部单中心经验。
Pediatr Blood Cancer. 2014 Aug;61(8):1341-6. doi: 10.1002/pbc.25004. Epub 2014 Feb 24.
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Genetic Heterogeneity of Beta Globin Mutations among Asian-Indians and Importance in Genetic Counselling and Diagnosis.亚洲印第安人β珠蛋白基因突变的遗传异质性及其在遗传咨询和诊断中的重要性。
Mediterr J Hematol Infect Dis. 2013;5(1):e2013003. doi: 10.4084/MJHID.2013.003. Epub 2013 Jan 2.
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Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates.全球新生儿镰状细胞血红蛋白病流行病学：基于当代地统计学模型的地图和人群估计。
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The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS).羟基脲长期治疗对镰状细胞综合征成年患者发病率和死亡率的影响：一项 17 年单中心试验（LaSHS）的结果。
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