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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Colombatto S, Fasulo L, Grillo M A

Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italia.

Int J Biochem. 1989;21(11):1197-201. doi: 10.1016/0020-711x(89)90003-7.

In vivo, adrenergic agonists promote an increase of ornithine decarboxylase activity (ODC) in chicken spleen, as opposed to a decrease in thymus and bursa of Fabricius. The increase is not due to the cell fraction separated on Lymphoprep, i.e. the spleen cells, but it could be due to the macrophages. 2. With spleen cells in culture, a marked increase of ODC activity is observed during the first 3 hr, followed by a decrease. 3. cAMP drastically decreases after 10 min in culture. 4. Adrenergic agonists promote a decrease of activity, both alpha and beta receptors being involved in these modifications. TPA promotes partial desensitization. 5. Selenite, which in vivo has the same effect as epinephrine, enhances ODC activity in culture. Propranolol partially counteracts this effect, while prazosin has a synergistic effect. TPA partially desensitizes spleen cells to selenite.

在体内，肾上腺素能激动剂可促进鸡脾脏中鸟氨酸脱羧酶活性（ODC）增加，而胸腺和法氏囊中该酶活性则降低。这种增加并非由于通过淋巴细胞分离液分离出的细胞组分（即脾细胞）所致，而可能是巨噬细胞的作用。2. 培养的脾细胞在最初3小时内ODC活性显著增加，随后降低。3. 培养10分钟后，环磷酸腺苷（cAMP）急剧减少。4. 肾上腺素能激动剂可促进活性降低，α和β受体均参与这些变化。佛波酯（TPA）可促进部分脱敏。5. 亚硒酸盐在体内与肾上腺素具有相同作用，可增强培养物中的ODC活性。普萘洛尔可部分抵消这种作用，而哌唑嗪具有协同作用。TPA可使脾细胞对亚硒酸盐部分脱敏。

Colombatto S, Fasulo L, Grillo M A

Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italia.

Int J Biochem. 1989;21(11):1197-201. doi: 10.1016/0020-711x(89)90003-7.

In vivo, adrenergic agonists promote an increase of ornithine decarboxylase activity (ODC) in chicken spleen, as opposed to a decrease in thymus and bursa of Fabricius. The increase is not due to the cell fraction separated on Lymphoprep, i.e. the spleen cells, but it could be due to the macrophages. 2. With spleen cells in culture, a marked increase of ODC activity is observed during the first 3 hr, followed by a decrease. 3. cAMP drastically decreases after 10 min in culture. 4. Adrenergic agonists promote a decrease of activity, both alpha and beta receptors being involved in these modifications. TPA promotes partial desensitization. 5. Selenite, which in vivo has the same effect as epinephrine, enhances ODC activity in culture. Propranolol partially counteracts this effect, while prazosin has a synergistic effect. TPA partially desensitizes spleen cells to selenite.

在体内，肾上腺素能激动剂可促进鸡脾脏中鸟氨酸脱羧酶活性（ODC）增加，而胸腺和法氏囊中该酶活性则降低。这种增加并非由于通过淋巴细胞分离液分离出的细胞组分（即脾细胞）所致，而可能是巨噬细胞的作用。2. 培养的脾细胞在最初3小时内ODC活性显著增加，随后降低。3. 培养10分钟后，环磷酸腺苷（cAMP）急剧减少。4. 肾上腺素能激动剂可促进活性降低，α和β受体均参与这些变化。佛波酯（TPA）可促进部分脱敏。5. 亚硒酸盐在体内与肾上腺素具有相同作用，可增强培养物中的ODC活性。普萘洛尔可部分抵消这种作用，而哌唑嗪具有协同作用。TPA可使脾细胞对亚硒酸盐部分脱敏。