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Shortcut route for generation of functional hepatocyte cells from human skin allogenically for autologous treatment of chronic liver diseases.

作者信息

Giri Shibashish, Bader Augustinus

机构信息

Applied Stem Cell Biology and Cell Technology, Biomedical and Biotechnological Center (BBZ), Universität Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany.

出版信息

J Clin Exp Hepatol. 2014 Mar;4(1):74-8. doi: 10.1016/j.jceh.2014.03.051. Epub 2014 Apr 18.

DOI:10.1016/j.jceh.2014.03.051
PMID:25755540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4188835/
Abstract
摘要

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Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.人成纤维细胞直接重编程为功能性和可扩增的肝细胞。
Cell Stem Cell. 2014 Mar 6;14(3):370-84. doi: 10.1016/j.stem.2014.01.003. Epub 2014 Feb 27.
2
Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.由谱系重编程诱导的具有药物代谢功能的人肝细胞。
Cell Stem Cell. 2014 Mar 6;14(3):394-403. doi: 10.1016/j.stem.2014.01.008. Epub 2014 Feb 27.
3
Mouse liver repopulation with hepatocytes generated from human fibroblasts.利用源自人成纤维细胞的肝细胞实现小鼠肝脏的再定植。
Nature. 2014 Apr 3;508(7494):93-7. doi: 10.1038/nature13020. Epub 2014 Feb 23.
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In vivo conversion of astrocytes to neurons in the injured adult spinal cord.成年脊髓损伤后星形胶质细胞在体内向神经元的转化。
Nat Commun. 2014 Feb 25;5:3338. doi: 10.1038/ncomms4338.
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Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.通过定义因子将成纤维细胞重编程为双潜能肝干细胞。
Cell Stem Cell. 2013 Sep 5;13(3):328-40. doi: 10.1016/j.stem.2013.06.017. Epub 2013 Jul 18.
6
Identification of small molecules for human hepatocyte expansion and iPS differentiation.鉴定用于人肝细胞扩增和 iPS 分化的小分子。
Nat Chem Biol. 2013 Aug;9(8):514-20. doi: 10.1038/nchembio.1270. Epub 2013 Jun 2.
7
Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model.人胎儿肝细胞系L-02在体外及急性肝衰竭模型中均表现出良好的肝功能。
Transplant Proc. 2013 Mar;45(2):695-700. doi: 10.1016/j.transproceed.2012.09.121.
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In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.在体重编程鼠心肌成纤维细胞为诱导性心肌细胞。
Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044.
9
Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell transplantation.基于血管灌注的高效人胎肝细胞分离方案用于基于肝细胞的治疗及细胞移植病例报告。
Liver Transpl. 2012 Feb;18(2):226-37. doi: 10.1002/lt.22322.
10
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.通过定义因子直接将小鼠成纤维细胞转化为肝细胞样细胞。
Nature. 2011 Jun 29;475(7356):390-3. doi: 10.1038/nature10263.