胶质瘤中环状指蛋白43的下调与预后不良相关。
Downregulation of ring-finger protein 43 in glioma associates with poor prognosis.
作者信息
Xi Shaoyan, Zhang Xinke, Chen Huadong, Zhong Zhihai, Lu Jiabin, Hu Wanming, Wu Qiuliang, Zeng Jing
机构信息
State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
Department of Pediatric Surgery, The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):490-6. eCollection 2015.
Ring-finger protein 43 (RNF43) has been identified as a RING-type E3 ubiquitin ligase. The overexpression of RNF43 results in a significant enhancement of cell growth, and knockdown of the expression of RNF43 by siRNAs exerts a growth-suppressing effect. RNF43 has been proposed as a tumor suppressor in colorectal cancers. However, its expression significance in glioma has not been well studied. In the present study, we found that the decreased expression of RNF43 was associated with poor prognosis by the Kaplan-Meier survival analysis (P < 0.001). Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival ([hazard ratio (HR) 0.547, 95% confidence interval (95% CI) 0.382-0.784, P = 0.001]). Collectively, our study demonstrated that RNF43 could be served as a potential prognostic marker for patients with this deadly disease.
无名指蛋白43（RNF43）已被鉴定为一种RING型E3泛素连接酶。RNF43的过表达导致细胞生长显著增强，而通过小干扰RNA（siRNA）敲低RNF43的表达则发挥生长抑制作用。RNF43被认为是结直肠癌中的一种肿瘤抑制因子。然而，其在胶质瘤中的表达意义尚未得到充分研究。在本研究中，通过Kaplan-Meier生存分析，我们发现RNF43表达降低与预后不良相关（P<0.001）。重要的是，多因素分析表明RN43是总生存的独立预测因子（风险比[HR]0.547，95%置信区间[95%CI]0.382-0.784，P=0.001）。总体而言，我们的研究表明RNF43可作为这种致命疾病患者的潜在预后标志物。
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