Department of Cardiothoracic Surgery, Xinhua Hospital School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai 200092, China.
Front Biosci (Landmark Ed). 2014 Jun 1;19(6):886-95. doi: 10.2741/4254.
Ubiquitination is a post-translational modification that plays a role in several cellular processes including cell cycle progression, cell proliferation, DNA replication and apoptosis. Ubiquitin-mediated signaling is frequently altered in cancer cells. Several tumor suppressors and oncogenes interact with enzymes of the ubiquitin-proteasome pathway that function in ubiquitin conjugation and deconjugation. Increasing evidence indicates that the ubiquitin-proteasome system (UPS) plays an important role in cancer development. Several small molecule inhibitors of the UPS have been applied to the treatment of cancer. The current review focuses on the role of the UPS in cancer development and the development of UPS inhibitors for cancer treatment.
泛素化是一种翻译后修饰，在几个细胞过程中发挥作用，包括细胞周期进展、细胞增殖、DNA 复制和细胞凋亡。泛素介导的信号在癌细胞中经常发生改变。几种肿瘤抑制因子和癌基因与参与泛素缀合和解缀合的泛素蛋白酶体途径的酶相互作用。越来越多的证据表明，泛素蛋白酶体系统（UPS）在癌症发展中起着重要作用。几种 UPS 的小分子抑制剂已应用于癌症的治疗。本综述重点介绍 UPS 在癌症发展中的作用以及用于癌症治疗的 UPS 抑制剂的开发。
