Zhao Xintong, Jiang Xiaochun, Wang Xiangming
Department of Neurosurgery, Yijishan Hospital, Wannan Medical College Wuhu, Anhui Province, P.R. China.
Department of Pathology, Yijishan Hospital, Wannan Medical College Wuhu, Anhui Province, P.R. China.
Int J Clin Exp Pathol. 2015 Jan 1;8(1):1036-40. eCollection 2015.
Pleomorphic xanthoastrocytoma (PXA) is a low grade tumor that occurs in supratentorial area of children and young adult. In the previous reports, PXA of spinal cord or multicentre was extremely rare. A 60-year-old patient of spinal PXA and periventricular tumor presented with waist pain and weakness of double legs for one month. Neuroimaging showed that a lesion at the level of L2-L3 and periventricular tumor. Postoperative microscopy indicated that WHO grade II PXA. Photomicrograph of the lesion showed spindle cells, marked nuclear and cytoplasmic pleomorphism, with foamy cytoplasm. Immunohistochemical staining showed that GFAP and S-100 were positive. This is a rare case of synchronous multicentric PXA. Physicians should be realized multicentric dissemination by meninges or cerebrospinal fluid in PXA patients. It is important to describe the particular case in order to better understanding of clinical features.
多形性黄色星形细胞瘤（PXA）是一种发生于儿童和青年成人幕上区域的低级别肿瘤。在既往报道中，脊髓或多中心的PXA极为罕见。一名60岁患有脊髓PXA和脑室周围肿瘤的患者，出现腰痛和双腿无力1个月。神经影像学显示L2-L3水平有一个病变以及脑室周围肿瘤。术后显微镜检查显示为世界卫生组织（WHO）二级PXA。病变的显微照片显示有梭形细胞，显著的核和胞质多形性，伴有泡沫状胞质。免疫组织化学染色显示胶质纤维酸性蛋白（GFAP）和S-100呈阳性。这是一例罕见的同步多中心PXA病例。医生应认识到PXA患者可通过脑膜或脑脊液发生多中心播散。描述该特殊病例对于更好地了解其临床特征很重要。
